Publications

•  Somatotrope GHRH/GH/IGF-1 axis at the crossroads between immunosenescence and frailty.

Bodart G, Goffinet L, Morrhaye G, Farhat K, de Saint-Hubert M, Debacq-Chainiaux F, Swine C, Geenen V, Martens HJ.
Ann N Y Acad Sci. 2015 Sep;1351:61-7.

• Novel ageing-biomarker discovery using data-intensive technologies.

Griffiths HR, Augustyniak EM, Bennett SJ, Debacq-Chainiaux F, Dunston CR, Kristensen P, Melchjorsen CJ, Navarrete SA, Simm A, Toussaint O.

Mech Ageing Dev. 2015 Nov;151:114-21.

• MARK-AGE population: From the human model to new insights.

Capri M, Moreno-Villanueva M, Cevenini E, Pini E, Scurti M, Borelli V, Palmas MG, Zoli M, Schön C, Siepelmeyer A, Bernhardt J, Fiegl S, Zondag G, de Craen AJ, Hervonen A, Hurme M, Sikora E, Gonos ES, Voutetakis K, Toussaint O, Debacq-Chainiaux F, Grubeck-Loebenstein B, Bürkle A, Franceschi C.

Mech Ageing Dev. 2015 Nov;151:13-7.

• Role of p38MAPK and oxidative stress in copper-induced senescence.

Boilan E, Winant V, Dumortier E, Piret JP, Bonfitto F, Osiewacz HD, Debacq-Chainiaux F, Toussaint O.

Age (Dordr). 2013 Dec;35(6):2255-71.

•  UV, stress and aging.

Debacq-Chainiaux F, Leduc C, Verbeke A, Toussaint O.

Dermatoendocrinol. 2012 Jul 1;4(3):236-40.

• Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project.

  Skytthe A, Valensin S, Jeune B, Cevenini E, Balard F, Beekman M, Bezrukov V, Blanche H, Bolund L, Broczek K, Carru C, Christensen K, Christiansen L, Collerton JC, Cotichini R, de Craen AJ, Dato S, Davies K, De Benedictis G, Deiana L, Flachsbart F, Gampe J, Gilbault C, Gonos ES, Haimes E, Hervonen A, Hurme MA, Janiszewska D, Jylhä M, Kirkwood TB, Kristensen P, Laiho P, Leon A, Marchisio A, Masciulli R, Nebel A, Passarino G, Pelicci G, Peltonen L, Perola M, Poulain M, Rea IM, Remacle J, Robine JM, Schreiber S, Scurti M, Sevini F, Sikora E, Skouteri A, Slagboom PE, Spazzafumo L, Stazi MA, Toccaceli V, Toussaint O, Törnwall O, Vaupel JW, Voutetakis K, Franceschi C; GEHA consortium.

  Exp Gerontol. 2011 Nov;46(11):934-45.

• Transcriptomic biomarkers of the response of hospitalized geriatric patients admitted with heart failure. Comparison to hospitalized geriatric patients with infectious diseases or hip fracture.

  Vo TK, de Saint-Hubert M, Morrhaye G, Godard P, Geenen V, Martens HJ, Debacq-Chainiaux F, Swine C, Toussaint O.

  Mech Ageing Dev. 2011 Mar;132(3):131-9.

• Differentially abundant transcripts in PBMC of hospitalized geriatric patients with hip fracture compared to healthy aged controls.

  Vo TK, Godard P, de Saint-Hubert M, Morrhaye G, Debacq-Chainiaux F, Swine C, Geenen V, Martens HJ, Toussaint O.

  Exp Gerontol. 2011 Apr;46(4):257-64.

• p38(MAPK) in the senescence of human and murine fibroblasts.

  Debacq-Chainiaux F, Boilan E, Dedessus Le Moutier J, Weemaels G, Toussaint O.

  Adv Exp Med Biol. 2010;694:126-37.

• Artefactual effects of oxygen on cell culture models of cellular senescence and stem cell biology.

  Toussaint O, Weemaels G, Debacq-Chainiaux F, Scharffetter-Kochanek K, Wlaschek M.

  J Cell Physiol. 2011 Feb;226(2):315-21.

• Serum N-glycan profile shift during human ageing.

  Vanhooren V, Dewaele S, Libert C, Engelborghs S, De Deyn PP, Toussaint O, Debacq-Chainiaux F, Poulain M, Glupczynski Y, Franceschi C, Jaspers K, van der Pluijm I, Hoeijmakers J, Chen CC.

  Exp Gerontol. 2010 Oct;45(10):738-43.

• Transcriptomic biomarkers of the response of hospitalized geriatric patients with infectious diseases.

  Vo TK, Godard P, de Saint-Hubert M, Morrhaye G, Swine C, Geenen V, Martens HJ, Debacq-Chainiaux F, Toussaint O.

  Immun Ageing. 2010 Aug 17;7:9.

• Proteomic profiling of human keratinocytes undergoing UVB-induced alternative differentiation reveals TRIpartite Motif Protein 29 as a survival factor.

  Bertrand-Vallery V, Belot N, Dieu M, Delaive E, Ninane N, Demazy C, Raes M, Salmon M, Poumay Y, Debacq-Chainiaux F, Toussaint O.

  PLoS One. 2010 May 3;5(5):e10462.

• Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo.

  Debacq-Chainiaux F, Erusalimsky JD, Campisi J, Toussaint O.

  Nat Protoc. 2009;4(12):1798-806.

• Transcriptomic biomarkers of human ageing in peripheral blood mononuclear cell total RNA.

  Vo TK, Godard P, de Saint-Hubert M, Morrhaye G, Bauwens E, Debacq-Chainiaux F, Glupczynski Y, Swine C, Geenen V, Martens HJ, Toussaint O.

  Exp Gerontol. 2010 Mar;45(3):188-94.

• Repeated exposures to UVB induce differentiation rather than senescence of human keratinocytes lacking p16(INK-4A).

  Bertrand-Vallery V, Boilan E, Ninane N, Demazy C, Friguet B, Toussaint O, Poumay Y, Debacq-Chainiaux F.

  Biogerontology. 2010 Apr;11(2):167-81.

• Age-related cellular copper dynamics in the fungal ageing model Podospora anserina and in ageing human fibroblasts.

  Scheckhuber CQ, Grief J, Boilan E, Luce K, Debacq-Chainiaux F, Rittmeyer C, Gredilla R, Kolbesen BO, Toussaint O, Osiewacz HD.

  PLoS One. 2009;4(3):e4919.

• p53 and ATF-2 partly mediate the overexpression of COX-2 in H(2)O (2)-induced premature senescence of human fibroblasts.

  Zdanov S, Toussaint O, Debacq-Chainiaux F.

  Biogerontology. 2009 Jun;10(3):291-8.

• Screening of senescence-associated genes with specific DNA array reveals the role of IGFBP-3 in premature senescence of human diploid fibroblasts.

  Debacq-Chainiaux F, Pascal T, Boilan E, Bastin C, Bauwens E, Toussaint O.

  Free Radic Biol Med. 2008 May 15;44(10):1817-32.

• Expression profiling of senescent-associated genes in human dermis from young and old donors. Proof-of-concept study.

  Borlon C, Weemaels G, Godard P, Debacq-Chainiaux F, Lemaire P, Deroanne C, Toussaint O.

  Biogerontology. 2008 Jun;9(3):197-208.