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Dynamics of Membranes & Endocytosis

Endocytosis is an essential process requiring orchestrated plasma membrane deformation for the uptake of nutrients from the surrounding cellular environment and turnover of plasma membrane components (Figure 1). Clathrin is the first coat protein involved in plasma membrane deformation identified over 50 years ago. However, the more recent discovery of clathrin-independent endocytic mechanisms led to the most challenging questions in the field: How are cargoes sorted in the absence of a clathrin coat and clathrin adaptor complexes? What are the proteins or complexes that link membrane curvature to cargo sorting?

Prof. Henri-François Renard