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Mitochondria and intracellular bacteria

Brucella, once in its host cells, traffics inside a vacuole called BCV (Brucella Containing Vacuole) that is able to interact with several components of the endosomal pathway. Afterwards, Brucella reaches a “permissive niche” sharing some properties and markers with the endoplasmic reticulum and in which bacteria multiply massively. As the role of mitochondria in innate immune response is now recognized (Lobet el al., Biochem. Phamarcol., 2015), we hypothesized that mitochondria might be affected and/or play a role during Brucella infection, intracellular trafficking and/or virulence, we thus study the effects of the bacteria on mitochondria in infected cells