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logo ATHEROMyeloperoxidase-oxidized LDLs and  macrophages

Cardiovascular diseases, the major cause of deaths in western societies and throughout the world are mainly due to atherosclerosis, a chronic inflammatory disease affecting mainly medium and large arteries (WHO, fact sheets of 2015). Local blood flow perturbations or injuries lead to an increased permeability of the endothelial layer, favoring lipoprotein infiltration in the intima where they get oxidized. The oxidized lipoproteins are atherogenic. They activate endothelial cells increasing their chemokine (eg. MCP-1) and cytokine (eg. IL-6) secretion, leading to the recruitment of monocytes that will differentiate into macrophages within the intima. Read more ...